Povietkina T. Particular features of the functional state of the autonomic nervous system in the mechanisms of forming urgent adaptation to the internal use of mineral water Naftusya in patients with pyelonephritis

Based on modern methods of clinical and laboratory diagnosis in 135 adults (apparently healthy and sick in chronical pyelonephritis), we have evaluated the functional state of ANS, state of the main regulatory stress implementing and stress limiting systems at a single intake of the mineral water and have proven the positive effect of MW Naftusya on sanogenesis processes. The adaptation mechanisms that were formed in response to intake of MW Naftusya consist in increasing the adaptive abilities of segmental links and in normalizing the tonus of suprasegmental ANS link with forming normotonia and sufficient level of vegetative reactivity in chronical pyelonephritis patients. According to regulation parameters dynamics, single internal intake of the mineral water Naftusya is a physiological irritant which participates forming the adaptation reaction. Activation of the sympathoadrenal system occurs in the early phase of urgent adaptation. It was found that changes of gastrin and glucagon values are monodirectional at the urgent phase of adaptation to internal use of the mineral water Naftusya. The dynamics of glucagon level in all the examined patients appeared in a moderate parameter increase within the normal values up to the 45th minute. Comparative analysis of the dynamics of insulin level showed a significant parameter increase within the normal values in all the examined patients up to the 15th minute. A more apparent gastrin dynamics is characteristic in chronical pyelonephritis patients that appears in a significant moderate increase up to the 15th minute with a further decrease till the 45th minute. The discovered features of neurohumoral regulation characteristics are predictor of balneologic reaction development and of result of the mineral water course use that forms a long-term organism adaptation.