Aleksevych K. Specifics of Necrotic Process in the Myocardium at the Background of Toxic Hepatitis (Experimental Researh)

Object - necrotic process in the attack against the background of toxic hepatitis; -z'yasuvaty goal peculiarities of adrenal cardiomyopathy against the background of acute toxic liver damage and assess antioxidant, cardioprotective and hepatoprotective properties meksydolu experiment on animals while damage to the heart and liver; methods - biochemical, morphological, statistics; results - experiments with non-linear albino male rats have revealed that adrenaline cardiomyopathy at the background of toxic liver damage involves activation of free radical oxidation and accumulation of TBA-active products and oxidative protein modification products within 3, 24, and 48 hours; under modeled pathology, decreased blood serum ceruloplasmin content as well as decreased catalase and reduced glutathione activity in the serum, myocardium and liver of affected animals have been found; within all research terms, increased erythrocytic intoxication index together with the medium weight molecules’ accumulation in all studied tissues as well as intensification of amino transferase, alkaline phosphatase, kreatine phosphokinase, and lactate dehydrogenase blood serum activity alongside with reduced activity in the myocardium and liver of affected animals have been found to occur; also found were profound disturbances of bioenergetic processes which revealed themselves in decreased succinate dehydrogenase and cytochrome oxidase activity as well as decreased myocardium and liver glycogen content alongside with increased blood serum glucose concentration and reduced pyruvic acid content in all studied tissues within 3, 24, and 48 hours; morphologic changes manifest themselves in the increase of cardiac hystiocyte necrosis and microcirculation disorders; Mexidol has been found to decrease necrobiotic processes in the myocardium and to suppress alteration processes with simultaneous stimulation of hepatocytes’ reparation within 48 hours, thus confirming its cardio-and hepatoprotective properties.