Pavlenko K. Effect of endogenic and exogenous growth stimulators on reparative regeneration mechanisms of osseous tissue

The solution of a scientific problem in the field of pathologic physiology is reported in the thesis. The problem is to detect calcium metabolism as a mechanism of intensity regulation, duration and sequence of stages of phase regeneration process of bone fracture, studying (making experimental studies on rats) morphological tela changes in the fracture and biochemical characters: ionic calcium and phosphorus in blood plasma and alkaline phosphatase kinesis. It is stated that alteration of stages of phase regeneration process of bone fracture comes with intensity changes of calcium release from repository and its ingress to osseous tissue in the fracture. The intensity of these processes increases at the stages of bone inflammation and turnover but during the emergence of tissue-specific elements in the fracture it decreases. Variations of calcium value positively correlates with (P043-) (that is Са2+ conductor in tela) value in blood plasma. Variations of above-stated ions value correlated with alkaline phosphatase activity which provides (P043-) mobilization from fusions and regulates Са2+ transport intensity in tela in the fracture. As a result alkaline phosphatase activity acts as intensity regulator of stages of this process. The usage of such exogenous growth stimulators as apitoxin maintains stage-by-stage process, but also forces it for 30 %. It happens due to emergence of "confluence" effect i.e. emergence of signs of the stage of following process with incompleteness of the previous one. Endogenic growth stimulators contained in platelet cut reparation time by means of other effects than apitoxin. Above all it is inflammation phase time reduction and severe intensification generation tissue specific elements phase. The strength of calcium metabolism doesn't change effectively. It indicates that there is a direct influence of endogenic growth stimulators on the strength of reparative processes. By this means the usage of endogenic and exogenous growth stimulators is capable not only of changing the osteogenesis speed but activating different process components as well.