Loshenko I. Optimization of the use of fibrinolysis inhibitors in complex intensive therapy of obstetric hemorrhage due to premature detachment of the placenta in the perioperative period

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U005051

Thesis Registration Form

0416U005051.pdf

Applicant for

Specialization

  • 14.01.30 - Анестезіологія та інтенсивна терапія

25-06-2016

Specialized Academic Board

Д 08.601.01

Essay

The scientific work is devoted to the assessment of the hemostatic system during obstetric bleeding disorders caused by premature detachment of the placenta, using the method of low-frequency piezoelectric thromboelastography; optimization of the use of inhibitors of fibrinolysis in this disease. Based on the results obtained it was proved that the pathology of premature detachment of the placenta accompanied by pronounced activation of fibrinolysis. This necessitates the use of inhibitors of fibrinolysis - tranexamic acid in doses of 15 mg / kg or aprotinin 300 000 KIU (kallikreininactivating units) intravenously. It is shown that tranexamic acid produces only antifibrinolytic effect, so its empirical use is possible. Aprotinin also affects the plasma hemostatic link, so its application is necessary to monitor the status of hemostasis by thromboelastography or coahulography. It is proved that tranexamic acid has an advantage over aprotinin in reduced dosage as to inhibition of fibrinolysis.

Read more

Files

aref.doc

dis.doc

акти впровадження--1--Ізмаїл 1 .jpg

акти впровадження--1--Ізмаїл 2 .jpg

акти впровадження--2--Коминт ЦРБ 1 .jpg

акти впровадження--2--Коминт ЦРБ 2 .jpg

акти впровадження--3--ООКЛ1 .jpg

акти впровадження--3--ООКЛ2 .jpg

акти впровадження--4--РД 1 а.jpg

акти впровадження--4--РД 1 б.jpg

акти впровадження--5--РД 2 а.jpg

акти впровадження--5--РД 2 б.jpg

Similar theses

0524U000034

Kateryna Y. Bielka

Critical incidents prevention during surgery under different types of anesthesia

0523U100253

Sidiuk Olena Ye.

Perioperative prevention of pulmonary complications in thoracic anesthesiology

0523U100115

Denysenko Anatolii I.

Personalized anesthetic management and intensive perioperative therapy in surgical interventions

0421U103029

Lisnycha Valentyna M.

Optimization of diagnosis and intensive care of sepsis-associated cerebral dysfunction

0521U101477

Filyk Olha V.

Clinical and physiological justification of the process of weaning from mechanical ventilation in children with different types of respiratory failure