Antypenko O. Tetrazolo[1,5-c]quinazoline(6H)-5-ones(thiones): synthesis, functionalization, physico-chemical and biological properties

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U005579

Thesis Registration Form

0416U005579.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

02-12-2016

Specialized Academic Board

Д 17.600.03

Zaporizhzhya State Medical University

Essay

This thesis is devoted to the development of synthetic protocols for tetrazolo[1,5-c]quinazolines and products of their hydrolytic cleavage - 2-(1H-tetrazolo-5-yl)anilines. The latter were used as a starting compounds for the synthesis of previously unknown potassium tetrazolo[1,5-c]quinazoline-5-thiones and corresponding thiolates, tetrazolo[1,5-c]quinazoline-5(6H)-ones, N,N-dialkyl-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)alkylamines, (tetrazolo[1,5-c]quinazolin-5-ylthio)carboxylic acids and esters, N-aryl(benzyl-)-2-[(5-oxotetrazolo[1,5-c]quinazoline-6(5H)-yl]acetamides and 1-(2-(1H-tetrazol-5-yl)-R1-phenyl)-3-R2-phenyl(ethyl)ureas.

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