Chepurna O. Method and system for selective superficial tumors irradiation depending on the availability of fluorescence

Object of research is a photochemical process of interaction of laser radiation with superficial tumors of biological tissues (BT) in the accumulation of the photosensitizer. The aim of the thesis is to improve the efficiency of remote antitumor photodynamic therapy (PDT) superficial tumors of soft BT by developing automated method and system for PDT selectively corrected fluorescent radiation superficial tumors with the contour of the tumor fluorescence. Methods: methods theories photobiology and laser medical technology, mathematical modeling; methods of computer analysis and image processing; methods of photodynamic laser therapy of malignant tumors; statistical methods; methods are based on the equations of biological tissues optics, laser medicine theory and optoelectronic devices; statistical methods. The theoretical results: further developed the method of fluorescence diagnostic morphological changes of superficial tumors by imaging fluorescent images of tumors. Improved is the mathematical model of laser irradiation in superficial tumors. For the first time are proposed the method PDT superficial tumors of soft biological tissues. Practical results are in development and implementation: automated sample-corrected fluorescent laser irradiation of superficial tumors in BT with PDT; methods of PDT treatments; software research fluorescence intensity of tumor and selecting the exposure; algorithm fluorescent images of tumors with PDT using digital filters. The degree of implementation - the results of the thesis introduced in Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology; PSME "Fotonika Plus"; in the educational process in Vinnytsia National Technical University in the department of biomedical engineering. Scope (industry) use - medicine.