Lisukha L. Effect of intermittent normobaric hypoxia on somatic vegetative status of children who live at radioactively contaminated territories

The dissertation is dedicated to the problem of effect of intermittent normobaric hypoxia (INH) of somatogenic level to restoring the somatic vegetative status of children who were born and are permanently living at radioactively contaminated territories. Content of 137Cs incorporated in children body, and correlation communications with indicators of heart rate variability (HRV) were revealed. The INH effect on the central and autonomic nerve systems (ANS), the cardiovascular system, external respiration, hemodynamics, blood, biochemical analyses with studying the pool of nitrogenous compounds and L-arginine, the saliva electrolytes were studied. Correlation between HRV parameters was established. The obtained results allow us to conclude, that the use of the course by INH s?ances with hypoxic gas mixture of 12 % oxygen in nitrogen has the positive effect on the state of the ANS. The increase in efferent parasympathetic activity, the decreased effect of sympathetic vasomotor center, the sympathetic-vagal index, indices of central contour controlling the heart rate were shown by comparison of the HRV results after INH in children aged from 6 to 11 years old at rest. The efferent parasympathetic activity was decreased in children aged 12-17 years. The activation of both ANS departments with predominance of the parasympathetic section was increased in examined younger children under using orthostatic test (during HRV recording). The activity of both departments with an advantage of sympathetic department was increased in older children. Indices of central contour of the heart rate were decreased. The duration of sensory motor reactions was decreased. The concentration of sodium and potassium electrolytes in the saliva was changed. Hemodynamic indices were improved, hemoglobin content was increased in patients of both age groups. The course of INH seances promoted increase of L-arginine in the blood plasma. Bronchospasm elimination was observed at all levels of the bronchial tree in most examined children.