Levchuk R. Pathogenetic features of enteral dysfunction in terms of brain, skeletal injuries and their combinations

Dissertation is devoted to the influence skeletal, brain injuries and combined injuries on the morphological and functional disorders of the small intestine and the mechanisms that determine it, during the earliest manifestations of traumatic disease. It is shown that in modeled injuries in the small intestine significantly increased content of primary and secondary products of lipid peroxidation, marked depletion of antioxidant parameters, which are dominated by 3 days in a traumatic brain injury and combination injury, and up to 7 days dominated in a combined injury. These disorders are accompanied by increased oxidative mechanisms in the brain. Comes the change ratio between immunoglobulins, from 1 to 7 days in serum increases the content of circulating immune complexes. Accumulate the average molecular weight of various factions through 7 days significantly higher in the combined injury than after skeletal and brain injuries. In conditions of simulated injuries disrupted the contents of interleukin-6, whose concentration at 3 and 7 days is significantly higher in the combined injury than in skeletal and traumatic brain injuries. These processes take place against a background of abuse suction function of the small intestine, there translocation of microorganisms, which increases from traumatic brain injury to combined injury with maximum manifestations after 3 days post-traumatic period.