Bibikova V. Pathogenetic mechanisms of morphological and functional changes in the cerebral cortex and subcortical brain structures in primary and recurrent hemorrhagic strokes in experiment

In this thesis, it has been conducted a comparative analysis of structural and functional changes in the head brain in dynamics of primary and recurrent hemorrhagic strokes and in the case of calcium channel blockade. It's been estimated the relationship between neurological deficit, behavioral and cognitive disorders and morphological changes in the cortex and subcortical structures in primary and recurrent hemorrhagic strokes respectively. It is shown in dynamics such behavioral changes as enhanced anxiety and emotionality of rats on the background of decline in behavioral responses, impairment of memory. Research results help solve the problem of pathogenesis of the disorders of the central nervous system, create the basis for the development of new algorithms for usage of several techniques (the scale "McGraw Stroke Index", "Open Field", etc). Quantitative analysis of brain changes in the dynamics of primary and recurrent strokes showed reliable loss of neurons in the sensomotor cortex of the brain.