Korobka O. Сlinical and genetic determinants of organ dysfunction in term infants with asphyxia

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U000848

Thesis Registration Form

0417U000848.pdf

Applicant for

Specialization

  • 14.01.10 - Педіатрія

28-03-2017

Specialized Academic Board

Д 64.609.02

The Kharkiv Medical Academy of Postgraduate Education, Ministry of Health of Ukraine

Essay

The thesis is devoted to improving the observation algorithm for newborns who suffered from asphyxia on the basis of studying the contribution of polymorphisms of renin-angiotensin system genes in the development of organ dysfunction in asphyxia. A multicenter "case-control" study was conducted, which included 72 full-term infants with asphyxia and 35 healthy newborns. It has been shown that the dominant model (4аа+4ba vs. 4bb) of eNOS gene significantly increases the chances of the child's developing asphyxia. The predictive models of hypoxic-ischemic encephalopathy, myocardial dysfunction, acute kidney injury, gastrointestinal dysfunction been developed. Newborn with the dominant model (СС+СА vs. АА) of AGT2R1 gene has high risks developing acute kidney injury, and newborn with the recessive model of eNOS gene has high risks developing gastrointestinal dysfunction. It has been shown that level of creatinine is associated with the dominant model (СС+СА vs. АА) of AGT2R1 gene, and level of NO2?+NO3? in urine is associated with the dominant models of eNOS and AGT2R1 genes. The observation algorithm for newborns with asphyxia during the early neonatal period has been developed.

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