Romanenko L. Hygienic evaluation of antimicrobial effect of silver nanoparticles composites

The thesis is devoted to investigation and providing hygienic assessment of the effectiveness of antimicrobial action of the composites with nanoparticles of silver and copper obtained by different methods. Modified suspension method was determined as most suitable for screening antimicrobial activity of soluble nanoparticles and compositions based on them. The antimicrobial activity was investigated and the benefits of nanomaterials and composites obtained by three methods were studied. It was established, that obtained composite system solution with silver nanoparticles "Silver Shield -1000" and different groups of antibiotics exceeds its components some times as for antimicrobial activity, so bactericidal concentrations of antibiotics were reduced. It was found that the antimicrobial activity of tissue impregnated with silver and/or copper nanoparticles remains high after washing and long-term storage. Usage of the drug white clay "Kremnevit" as a component of composite with silver nanoparticles proved to be reasonable. High antimicrobial activity and sorption action of the composite-based drug "Kremnevit" with silver nanoparticles was revealed. Studied composites can be used at all levels of hospital hygienic actions - to create medicines, bandages and medical personnel clothing.