Yakushev A. Transplantation of mononuclear cord blood stem cells in a complex conservative treatment of refractory heart failure

The dissertation is devoted to treatment of patients with refractory (to standard schemes of conservative treatment) heart failure (HF), which are on the waiting list for heart transplantation. In order to enhance myocardial contractility in scheme of conservative treatment patients were intravenous administrated the cell preparation "Cryopreserved human umbilical cord blood". We have found that cord blood stem cell transplantation (CB SCT) reduces the HF severity, increases the effectiveness of conservative therapy, improves left ventricular systolic function, significantly improves the quality and duration of life of patients, compared with patients who received only conservative therapy. This study revealed that CB SCT does not lead to complications such as proarrhythmogenic influence, acceleration of progression of coronary heart disease and reactivation of persistent viral infections on the background of possible changes in immune statе. In this work the original algorithm of CB SCT in the scheme of conservative treatment of HF was developed and proposed for use.