Zhytnikova M. Conformations of the sugar-phosphate DNA backbone and protein-nucleic acids recognition

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U001732

Thesis Registration Form

0417U001732.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

30-03-2017

Specialized Academic Board

Д 64.051.13

V.N. Karazin Kharkiv National University

Essay

Object of investigation: mechanisms of influence of sugar-phosphate DNA backbone transitions on the structural and physical properties of DNA, which can be important for protein-DNA recognition. Methods of investigation: statistical analysis and methods of bioinformatics. Scientific novelty: data on the one of the mechanisms of indirect recognition, which is based on the changes of the structural and physical parameters of DNA at conformational transitions of the sugar-phosphate DNA backbone (namely gamma angle and conformation of deoxyribose). Practical meaning: application in biophysics, molecular biology and bioinformatics.

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Files

aref.doc

diss.PDF

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