Dubovyk Y. Pathogenetic value of vitamin K cycle genes polymorphisms for ischemic atherothrombotic stroke development

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U002089

Thesis Registration Form

0417U002089.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

12-05-2017

Specialized Academic Board

Д 55.051.05

Sumy State University

Essay

Thesis is dedicated to the study of vitamin K cycle genes polymorphic variants impact on the development of ischemic atherothrombotic stroke (IAS). The data showed that G-1639A polymorphism was related to IАS, regardless of adjustment for age, sex, body mass index, smoking status and arterial hypertension. The risk for IАS in -1639A allele carriers (OR = 2.138, P = 0.015) was higher than in individuals with G/G genotype. Analysis of C1173T genotypic association with IAS under the four common models of inheritance did not find the link with ischemic stroke either in total group or subgroups by gender, BMI and BP under different inheritance models.

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