Gancheva E. Clinical and laboratory evaluation of pregnancy and prevention of complications in women with pyelonephritis.

The work is devoted to the clinical and laboratory evaluation of pregnancy and prevention complication in women with pyelonephritis. In the dissertation indices the theoretical foundations of research on the condition of fetoplacental system in this pathology. Define the etiological factors of pregnancy and especially during exacerbation of chronic and gestational pyelonephritis to determine the pathogenesis of this disease during pregnancy and its correction. The author studied characteristics of the immunological status, vascular endothelial growth factor and factors of endothelial dysfunction at an exacerbation of chronic pyelonephritis of pregnant and gestational pyelonephritis. The role-specific destructive process in the kidney enzyme transamidinase, the main indicators of the system of hemostasis in the blood of pregnant women during exacerbation of chronic and gestational pyelonephritis to determine the prognostic markers of the development of this pathology.In the paper identified the interleukin concentrations in the blood of pregnant women with pyelonephritis and studied indicators disorders of mineral metabolism in women with this disease as risk factors for placental dysfunction. Analysis of lipid metabolism during exacerbation of chronic and gestational pyelonephritis as a key factor in the adaptive changes in the body. New data about the peculiarities of development of morphological and functional changes in the placenta in pregnant women with acute exacerbation of chronic and gestational pyelonephritis after carrying out medical and preventive complex. Differentiated pathogenetically grounded approach and proposed a new method of karbogentherapy in pregnant women with pyelonephritis, will reduce the frequency of obstetric and perinatal complication and improve morbidity and infant mortality.