Bilyk G. The clinical relevance markers of risk factors for airway remodeling in asthma in school age children

Object - asthma in school-age children with different risk remodeling of the airways in acute clinical and laboratory remission; goal - improving the treatment of asthma in children by examining the clinical values of airway remodeling risk and dynamic evaluation of their impact on achieving control of the disease; methods - clinical, general laboratory tests, biochemical, immunological, cytological, histochemical, instrumental, allergological, math; results - found that children with high risk of remodeling characteristic is often born weighing less than 2500 grams, inheritance atopic diseases for the pedigree of both parents, the presence of drug allergy situation where the source of prolonged exposure to tobacco smoke acts have polymorphisms of genes GSTM1, or GSTT1 and lack of eNOS gene mutation; they often determined blood eosinophilia more than 10%, the content of total IgE blood more than 750 IU / mL, higher proteolytic and fibrinolytic activity exhaled breath condensate and increased content of nitric oxide metabolites condensate; the high levels of VEGF in sputum supernatant and / or MMP-9 in children during the years of monitoring often formed a severe form of asthma and bronchial hypersensitivity to inhaled histamine while reducing their lability; found that children with high content in sputum biomarkers studied remodeling marked reduction of eosinophil cationic protein in sputum and increase myeloperoxidase activity in them; found that increased proteolytic activity of exhaled breath condensate is associated with a high risk of bronchial remodeling; shows that the presence of asthma patients of high or medium risk remodeling significantly reduces the effectiveness of supervisory regulated treatment