Tkachuk B. Determination level of hydration a patient on program hemodialysis

The object of research - the process of redistribution of fluid in the patient's body during the procedure of program hemodialysis. The purpose of the study is to increase the reliability of non-invasive determination of the moment of reaching the "dry weight" of patients during the procedure of program hemodialysis by developing a method and creating algorithmic solutions for determining the state of hydration. Methods of the study are elements of the theory of nonequilibrium thermodynamics; The basics of the theory of electric circuits; simulation calculations in MathCad environment; elements of statistical analysis. Scientific novelty - for the first time a mathematical model of the process of fluid transfer in the patient's body during ultrafiltration was obtained for the first time, based on the theory of nonequilibrium thermodynamics, which allowed to reveal a mutual functional dependence of the filling of liquid sectors in the PHD procedure, - an improved electrophysical model of the living matter of Frick-Morse, due to the division of liquid sectors , Which made it possible to use the method of bioimpedansometry to determine the state of hydration of the patient in the PHD procedure; -the method of determining the "dry weight" of the patient has been improved. Which, unlike existing ones, by means of continuous control of the components of the volume of ultrafiltrate, by the method of bioimpedansometry, allows to automate and objectively determine the moment of achievement of the state of normhydratation at PHD. The degree of implementation: KZOZ "OKTSUN named after V.I. Shapoval"; NTUU "KPI named after I. Sikorsky"; NTU "KhPI". Sphere of use - the branch of medical instrumentation.