Shulga M. Perioperative correction of oxidative-reduction metabolism in complex treatment of patients with breast cancer.

In the prospective randomized controlled research that included 126 patients with breast cancer the role and realization mechanisms of oxidative stress have been studied in the complex treatment, particularly in anaesthesiological provision of surgical treatment and intensive care. Following aspects have been studied: metaboliс changes connected with amount and duration of neoadjuvant therapy which define the peculiarities of pre-operational and intraoperational intensive care and are conditioned by clinico-functional state of different components of pro- and antioxidant defense of patients. This serves as a factor of clinical individualization of antioxidant correction. Methods of control (monitoring) and regulation of main vital functions affected under the influence of the disease, operational trauma etc. have been improved in complex treatment of breast cancer with surgical operations in form of quadrantectomy of breast with lymphodissection. The role and mechanisms of oxidative stress realization at the stages of complex treatment of patients with breast cancer, in particular with anesthetic support of surgical treatment and intensive care taking into account the age of patients, their cognitive function, has been studied for the first time. A novel approach has been developed in securing of patients and compensation of organism's vital functions affected by the disease, operational trauma etc. on the stages of complex treatment of breast cancer with surgic invasion in form of breast quadrantectomy with lymphodissection.