Cherniavska I. Modifying influence of voflibose on the indexes of carbohydrate metabolism in persons with impaired glucose tolerance and high cardiovascular risk

The dissertation presents the new decision of current task of clinical endocrinology: аn approach to the method of type 2 diabetes mellitus (DM) prevention based on study of clinical effectiveness and safety of voglibose in patients with impaired glucose tolerance (IGT) and high cardiovascular risk. There was determined that antihyperglycemic therapy with voglibose for six months in combination with lifestyle modifications assists the significant decrease of postprandial hyperglycaemia, fasting blood glucose and HOMA-IR index in persons with IGT and cardiovascular risk. 82.2% patients obtain normal glycemic level in 2-hours glucose tolerance test after treatment with voglibose. Therapy with voglibose in dose 0.6 mgs/d in combination with lifestyle modifications results in significant decrease of body weight, body mass index and waist circumference in persons with IGT and high cardiovascular risk. Efficiency of the additional setting of voglibose in combination with lifestyle in persons with IGT and different level of cardiovascular risk confirmed by the positive reliable dynamics of decline of basic indexes of cardiovascular risk using the SCORE scale. High cross-correlation dependence is set between cardiovascular risk using the SCORE scale and by the risk of type 2 DM development using the FINDRISС scale.