Bobruk S. Features of the course and improvement of the treatment of infectious mononucleosis in children, taking into account microbiome and local immunity of the mucous membranes of the oropharyngeal zone.

The dissertation to improve the treatment of children on the basis studing the peculiarities of clinical manifestation, microbiocenosis and indicator of immuniti in mucosal orofaryngeal area.The severity of the disease is occurred also due to an opportunistic bacterial infection, which is activated because of changes in components of the mucosal immune system. All examined children had tonsillitis. An increase of presence of bacterial species with a high pathogenic potential (S. aureus, P. aeruginosa) was detected, and the prevalence of Gram-negative bacterial flora represented by enterobacteria (E.coli, Enterobacter and Klebsiella), which are not typical for this biotope. In the course of scientific research, it was found that lactoferrin level had 5-fold increased, which was directed for reducing the inflammatory process in the oropharynx. The accession of interferon alpha 1 in oropharyngeal secretion, which is produced by T- and B- lymphocytes in patients with IM, was also logical, while TNF-? staying in normal range, what leads to chronization of inflammatory process. New effective schemes of integrated treatment patients with IM with the using of antiseptics have been developed, and the expediency of using the drug decamethoxin in the complex treatment of patients with IM.