Altybaeva D. Diagnosis and treatment of adenomyosis combined with hyperplastic processes of the endometrium in women of reproductive age

Thesis is devoted to the problem of the diagnostic of endo- and myometrium benign pathology algorithm improvement using modern diagnostic methods and increasing effectiveness of conservative therapy of this pathology in reproductive-aged women by the means of complex hormonal therapy. In the investigation clinic-statistical analysis was conducted, risk factors of benign uterus pathology in reproductive-aged patients were identified. The influence of hormonal therapy hestagen and a-GnRH on clinical course and homeostasis indexes in women with adenomyosis, endometrial hyperplasia and combined uterus pathology was learned in dynamics. New pathogenesis units in benign uterus pathology by means of immune system dysfunction that was defined in decreased levels of cytotoxic index of NK-cells were revealed. Complex hormonal therapy in reproductive-aged women with combined benign uterus pathology was developed and estimation of influence on oncomarker indexes, immune status, steroid hormones and hematological indexes in observation dynamics was conducted. Degree estimation scale of severity level of benign uterus pathology in reproductive-aged women that assists in patients conducting tactics definition and differential approach to the treating method of this pathology was worked out.