Shmyga T. Immunological and molecular genetic markers in patients with recurrent herpetic infection first and second types and tactics of driving.

Dissertation is devoted to the study of clinical, immunological and molecular genetic characteristics of patients with recurrent herpes simplex virus infection first and second types of conditions for the formation of their infertility. At the same time increased the number of CD8+- cells (р<0,01) to complete specific cytotoxic lymphocytic protection: women (1,5 times), in patients with the presence of HSV DNA in saliva 1/2 (1,6 times) with frequent recurrent infections HSV 1/2 (1,7 times) and infertility (2,5 times).For the first time studied the features fusion receptor antagonist of interleukin-1 (IL-1Ra) in serum of infertile patients with recurrent HSV infection 1/2. Established in patients with recurrent herpes simplex reduction of the inflammatory cytokine to 384,4 pg/ml, whose concentration in the control was 619,5 pg/ml (р<0,001). This is especially manifested in men (264,7 pg/ml, р<0,05), with frequent recurrences of HSV 1/2 (304,4 pg/ml, р<0,05) and highest in infertility (244,4 pg/ml, р<0,001). The correlation between the amount of CD4 + 25 + 127 regulatory cells in peripheral blood and the concentration of IL-1Ra in serum infertile patients was detected - the decrease in IL-1Ra level was accompanied by a decrease in the number of CD4 + 25 + 127 regulatory cells (r = + 0,32; р<0,05). For the first time these immunogenetic features of patients with recurrent herpes simplex in violation reproduction. At the Influence of recurrent infections HSV 1/2 expression of serum miR-155 in patients with idiopathic infertility was found increasing levels of miR-155 with frequent relapses and sterility of the pathogen to the values of 3,83 U/6 and 4,08 U/6 respectively compared to the control - 1,05 U/6.