Mochulska O. Clinical and pathogenic grounds for immunologic tolerance induction at the background of the allergen-specific therapy in the children with atopic dermatitis.

Dissertation is dedicated to studying of clinical-immune-morphological features of the course of atopic dermatitis in children. It has been established that changes in cellular immunity are manifested at all levels – quantitative (imbalance between some subpopulations of T- and B-lymphocytes) and functional (violation in differentiation of T-lymphocytes and profile of their cytokine secretion): decrease the concentration of general T-lymphocytes population (CD3), increase of T-lymphocytes helpers (CD4), decrease of T-lymphocytes suppressors (CD8), increase of immunoregulatory index (CD4/CD8), increase of B-lymphocytes (CD19) and T-lymphocytes natural killers (CD16), decrease the concentration of IL-2 and increase of IL-4, IL-6, IL-10. Changes in humoral immunity are manifested by decrease the concentration of IgA, increase of IgE and IgG in the blood. The concentration of total IgE and serum histamine in children with atopic dermatitis are sensitive systemic biomarkers of sensitization, activity of allergic inflammation that interdependent on the clinical course severity of the disease. Different risk factors of allergy were researched. New data on the spectrum of allergic sensitization in children with atopic dermatitis were obtained. The clinical efficiency of complex treatment with combined use of allergen-specific immunotherapy and prolonged course of probiotics at atopic dermatitis in children were developed, pathogenetically substantiated and clinically proven.