Svizhak V. TAntimicrobial activity and prospects of use of new 5-carbofunctionalized imidazole derivatives in medicine.

Object - museum and clinical strains of opportunistic microorganisms, 5-carbofunctionalized imidazole derivatives; aim – microbiological substantiation of the development of highly effective medicinal antimicrobial agents by in vitro and in vivo studies of the antibacterial and antifungal activity of compounds obtained as a result of targeted organic synthesis of various types of 5-carbofunctionalized imidazole; methods – microbiological, biological, statistical; results – for the first time, by using 38 museum and 39 clinical strains of various taxonomic positions of bacteria and mycomycetes there was characterized the antibacterial and antifungal activity of 161 compounds, which had been obtained in a result of directed organic synthesis of the 5-carbo-functionalized imidazole derivative, which resulted in promising further studies for the development of antimicrobial medications appointments; for the first time prospective 7 compounds of 5-carbofunctionalized imidazole were detected; for the first time there were established the slow formation of resistance of Staphylococci to 5-carboconfunctionalized imidazole, their antimicrobial activity varies insignificantly under the influence of various factors (pH of the medium, increased serum protein concentration) and remained statistically significantly high to suppress the growth and multiplication of pathogens, accordingly to this a positive preventive and curative effect in their clinical application was expected; for the first time, the chemotherapeutic efficacy of 2 compounds of 5-carbo-functionalized imidazole was proved in vivo while using the models of experimental trichophytosis and experimental localized Staphylococcal purulent soft tissue infection; branch – medicine.