Melnyk N. Toxicological and hygienic characteristics of chronic effects of lead nanoparticles on intact skin and criteria for evaluating their hazard (experimental research).

In the dissertation, on the basis of experimental toxicological and hygienic researches, theoretical generalization and practical solution of the actual task of occupational health on evaluation of the emission of nanoparticles (NPs) into the air during simulation of an experimental model of the technological process of lead recovery and determination of chronic effects of NPs of PbS on intact skin depending on their physical and chemical characteristics has been made.The regularities and peculiarities of NP emissions in the air at different stages of the technological process of lead recuperation have been studied; there have been defined physico-chemical properties of NPs (types, size, chemical composition) in air samples selected at different stages of the technological process and an assessment has been given on their danger; a comparative analysis of the filter cloth in the aerosol filters "AFA-HA" and membrane filters "MILIPOR" and " SINPOR" has been made. A model of the chronic effect of nonorganic lead compounds, presented as micro- and NPs in the experiment of laboratory animals has been reproduced; the effect of micro-and lead NP resorption through the skin has been revealed and their comparative characteristics is given; morpho-functional changes in the skin in the chronic effect on the undamaged surface of PbS NPs different by their size are studied and regularities, peculiarities and possible mechanisms of their resorption through the skin depending on the size of the NPs have been defined as well as the criteria for the assessment of the danger of lead NPs in their effect on the undamaged skin.