Ryshchak N. Synthesis, physicochemical properties and biological activity of 3-(4-oxo-2-methylquinoline-3-yl)propanoic acids and their derivatives

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0418U001862

Thesis Registration Form

0418U001862.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

08-06-2018

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The dissertation is devoted to the synthesis of new biologically active compounds the derivatives of quinoline-4-ions, the establishment of a pharmacological profile for synthesized substances, the development of analytical methods for the creation of quality control methods on perspective AFI among the derivatives of 3-(2-methyl-4-oxo-1,4-dihydroquinoline-3-yl)propane acids. 89 new compounds were synthesized and substances with pronounced antimicrobial, anti-inflammatory, anticoagulant and hemostatic activity were detected among them. The regularities of the "structure-activity" connection were established. The "leader compound" with pronounced haemostatic action was selected and patented.

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