Nechytajlo O. The pathophysiological mechanisms of the endothelial dysfunction and microcirculatory disturbances formation in patients with diabetes mellitus with purulent-necrotic complications

Object - disturbance of microcirculation and endothelial function in patients with type 2 diabetes mellitus and purulent-necrotic complications; the goal - to find out the pathophysiological mechanisms of the formation of endothelial dysfunction and microcirculation disorders in patients with diabetes mellitus combined with purulent necrotic conditions, to establish their prognostic value for the onset of critical ischemia of the lower extremity tissues and to justify methods for correcting these disorders; methods - clinical and laboratory, instrumental, mathematical and statistical; results - the obtained data allow to expand existing ideas about the state of the microcirculatory bed in the diabetic foot syndrome in patients with type 2 diabetes mellitus. Methods for investigating microcirculation and endothelial function, which are minimally invasive and available for use in inpatient departments and regardless of the severity of the patient's condition, are proposed. The pathogenetic explanation of the feasibility of using L-arginine is given.