Zalizna K. Reactions based on the products of the 5', 6',7',8'-tetrahydro-1'H-spiro[cyclohexane-1,2'-quinazoline]-4'(3'H)-one rearrangements

In the dissertation, an electrophilic rearrangement of derivatives of pyrimidine-4-ones with a heminal system of N1-C2-N3 is considered, which, due to the peculiarities of the structure of the parent compounds, leads to the formation of cyanderivatives bisanilated pyridines or the product of recycling of intermediate intermediates and acyclic benzamide derivatives. As a result of the imine-enaminal tautomerism in 1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile and carboxamide, and keto-enol tautomerism in cyclohexanone-2-carboxamide, the possibility of interaction with electrophilic reagents. It is shown that the reaction takes place under the scheme of accession-splitting or aza-yen synthesis. The obtained products expanded a number of examples of chemical modifications of derivatives of hydrogenated acridines, hydrazones and indoles. It has been shown that in spite of the reduced electrophilicity of Carbon atoms, formaldehyde groups of 4,5-diformyl-2,3,6,7,8,10-hexahydroacridine-8a(1H)-carbonitrile are readily reacted with N-nucleophiles to form polidentate ligands . By methods in vivo studies, compounds with high levels of biological activity have been identified.