Al-Hashimi S. State of the immunity system under conditions of arterial hypertension

The thesis is studying the state of the immunity system and non-specific resistance of human organism of people with arterial hypertension of different stages. The character of damages of immune measures under hypertension of different stages was defined based on analysis of state of cellular and humoral components of the immunity system, non-specific anti-infective immunity, 24-hour blood pressure monitoring, and changes in total cholesterol level. Peculiarities of state of cellular and humoral components of immunity system under arterial hypertension with complications were defined; typical changes of daily fluctuation of blood pressure for arterial hypertension with complications were specified. Immune status considering clinical features was studied, groups of hypertensive patients with crisis, without crisis and with microalbuminuria were selected. All of the patients had moderate form of arterial hypertension (second stage) with blood pressure 160-179/100 mmHg. Maximum changes of cellular components of the immunity system were found in patients who had been sick for more than 10 years which points at functional load and formation of secondary immunodeficiency of cellular component. Indicators of humoral component of the immunity system had certain changes in hypertensive patients who had been sick for more than 10 years. The received results show that there was immune perturbation, the immunity system tension which, if stays for a long time could possibly cause compensatory mechanisms failure. Studied immunological indicators allowed us to suppose that immunity system in hypertensive patients was like early evidences of development of autoimmune inflammation and participation of immunocompetent cells in pathophysiological processes typical for arterial hypertension.