Donnyk T. Role and mechanisms of participation of psycho-emotional disorders in disregulative pathology among patients with late effects of closed light craniocerebral injury and their correction by method of programmed sensory deprivation

The dissertation presents results of complex research of the main clinical-neurological, hemodynamic and metabolic changes in organisms of patients with late effects of closed craniocerebral injury. Among 100 patients with vegetative dysfunction syndrome (SVD) in late period of closed craniocerebral injury are detected subjective and objective disorders of vegetative suprasegmental structures activity, testifying of desynchronosis and disbalance of their activity that is of forming disregulative pathology in these divisions of vegetative nervous system (VNS). The detected disorders were correlated with changes of hemodynamics and disorders of neurohumoral element in sympathetic-adrenal system, bioelectrical activity of the cerebral structures. Simultaneously among these patients took place cognitive functions and psycho-emotional disorders. Treatment of patients with vegetative dysfunction syndrome resulting from closed craniocerebral injury with programmed sensory deprivation which is directed on normalization of functional systems of limbic and hypothalamic systems activity by virtue of decreasing afferent impulsive loading and strengthening of intersystem processes of restoring synchronization and balance, improved state of cognitive and psycho-emotional displays. At the same time improved, and in some indexes were also normalized clinical-neurologic, hemodynamic and bioelectrical indexes of the state of suprasegmental structures of vegetative nervous system. The last are to be considered as decreasing of disregulative pathology among patients with vegetative dysfunction syndrome as a result of closed craniocerebral injury by virtue of restoring central regulation of suprasegmental structures of vegetative nervous system. The data obtained certifies of the fact that restoring of activity of functional systems of limbic and hypothalamic regions of the brain can be considered as pathologically determined ways of correction for vegetative nervous system activity disorders among patients with closed craniocerebral injury.