Mykhalchyk S. Correction of metabolic disorders in the prevention and treatment of diabetic retinopathy.

The dissertation is devoted to the effectiveness increase in prevention and treatment of diabetic retinopathy for patients with insulin-dependent diabetes mellitus and correction of antioxidant system disorders (AOS) by short-chain drugs based on new scientific data on the peculiarities of changes in antioxidant processes in patients' blood depending on the stage. The relationship between oxidative stress activation, NO dysfunction and the factors regulating angiogenesis in the formation of diabetic retinopathy is first shown. It has been shown for the first time that the antioxidant from the group of short-chain carotenoids can cause regression of molecular-biochemical and clinical signs of retinopathy in patients with insulin-dependent diabetes mellitus. It was first established that under the action of AOS of short-chain carotenoids, the expression of key molecular regulators of angiogenesis-pigmentary factor of epithelial origin (PEDF) and vascular endothelial growth factor (VEGF) -regulations, as well as indicators of the NO-expression of iNOS expression and the maintenance of a stable metabolite NO-was normalized.