Clinical symptoms of shigellosis as well as duration depend on present background infection. In children, infected with H. Pylori, significantly higher body temperature values, greater number of episodes of vomiting, abdominal distention, epigastric location of pain, increased pain after food intake and more frequent presence of pathologic admixture in the excrement were recorded. The above-mentioned symptoms in infected children lasted longer that resulted in more long-term hospitalization period. In children, who were not infected with H. Pylori, the complete blood count showed more significant increase of band and segmented neutrophils, decreased lymphocytes number and enhanced blood sedimentation rate (р<0.05) along with absence of significantly decreased hemoglobin both in acute period and in reconvalescence period in comparison with the findings in children infected with H. Pylori, (р<0.001) and the stool test showed significantly less frequent presence of indigested fiber, vegetable fiber and muscular fiber, t≥2.0. In children without background infection, apparently significant increase of anti-inflammatory IL-1β, TNF-α levels was observed in acute period and, in reconvalescence period, fast and statistically significant decrease of these levels and significantly higher (by 1.96 times) anti-inflammatoryIL-4 levels were estimated, while children, infected with H. Pylori, showed apparently longer increased level of anti-inflammatory cytokines content without substantial tendency to decrease prior to reconvalescence period and absence of considerable alteration in IL-4 content in different disease periods, (p˃0,05). In patients with shigellosis, infected with H. Pylori, deficient immune response of T-helper (СD4+) when activating suppressor activity of cytotoxic T-lymphocytes (СD8+) was revealed. Convalescence was observed alongside preservation of disturbance of cellular arm of the immune response, pronounced deviation from CD-lymphocytes level standard. In acute period of shigellosis, Zn blood content of children infected with H. Pylori was significantly lower than that one in uninfected patients and was somehow increased prior to early reconvalescence period, however it was still significantly different from referential values, and copper level was significantly higher than that one in uninfected patients, p<0.001; it was closer to referential values prior to early reconvalescence period in patients of both study groups. In patients without background infection, substantially increased sIgA level in the excrement in comparison with the values in children, infected with H. Pylori, p˂0.05, was reveled. The study has made it possible to develop a diagnostic algorithm focused to assess presence of infection with H. Pylori in children with shigellosis. The ways to improve treatment of children with shigellosis, infected with H. Pylori, comprising adequate dietary therapy, aluminium phosphate gel, with due regard for the age of a child – applying medical agents which contain zinc, in acute period as well as at rehabilitation stages, were theoretically substantiated.
