Al Salim A. Disadipokinemia and polymorphism of the leptin receptor gene (LEPR Q223R) in coronary heart disease and its comorbidity with type 2 diabetes

In the thesis the substantiation of increasing the effectiveness of diagnosing and predicting the course of the stable coronary heart disease (CHD) for comorbidity with type 2 diabetes mellitus (DM) are presented on the basis of the study of the relationship between cardiometabolic risk factors, structural-functional state of the left ventricle with the leptin receptor gene polymorphism (LEPR Q223R) and adipokine status in 147 patients. The clinical and pathogenetic features of patients with stable CHD with post-infarction cardiosclerosis associated with type 2 DM are determined, depending on the polymorphism of the leptin receptor gene LEPR Q223R and the adipokin status. It is shown that homozygous carrier of allele R increases the risk of comorbidity of stable CHD with type 2 DM (OR = 1.58). The polymorphism of the LEPR Q223R gene is a factor of disturbance of adipokin status and deepening of the proatherogenic pattern in patients with stable CHD, especially with comorbidity with type 2 DM. The genotype LEPR RR is reliably associated with hyperleptinemia, disadipokinemia, and traditional cardiometabolic risk factors (obesity, dyslipidemia, insulin resistance, and increased CRP) in men with postinfarction cardiosclerosis. RR genotype and integral index of disadipokinemia (Ig adiponectin/leptin) were independent predictors of the left ventricle remodeling by type of eccentric hypertrophy and reduction of the ejection fraction. Keywords. Coronary heart disease, leptin, adiponectin, leptin receptors, polymorphism, remodeling of the myocardium. Branch - medicine.