Malʹtseva V. Age-related features of the realignment of the spinal motion segment of the lumbar spine of rats after lead exposure

The dissertation presents the results of the experimental study of the influence of lead on the reconstruction of the vertebral bodies, intervertebral discs and facet joints that make up the vertebral motor segment of the lumbar spine in the young rats and the mature rats with modeled osteoporosis both at the tissue and cell levels. In addition, the results of lead exposure on the redistribution of types of collagen fibers in the matrix of the vertebral bodies and the intervertebral discs are presented, and the accumulation of lead in these structures is analyzed. We found that the loss of bone mass in the vertebral bodies of young rats is associated with suppression of the growth of the vertebral bodies and increased resorptive activity of osteoclasts, and in the rats with osteoporosis, due to the sensitivity of osteoblasts to the action of lead on the background of osteoporosis. In the intervertebral disc, especially in young animals, observed a decrease in the height of the intervertebral disc in the central and outer regions is associated with a violation of the matrix structure and a decrease of cell density, due to dystrophic disorders. Degenerative changes in the facet joints of rats have been established, with a greater manifestation in mature rats with osteoporosis.