Zanko O. Diagnosis, treatment and prevention of hyperproliferative diseases of endometrium in postmenopausal women.

The work is focused on optimization of methods of early diagnosis, prevention and treatment of hyperproliferative diseases of endometrium in postmenopausal women based on the study of existing medical illness, hormonal homeostasis and morphofunctional features of endometrium. The extragenital morbidity structure was studied, carbohydrate metabolism status, blood lipid concentrations and hormonal homeostasis were evaluated, leptin and 25-hydroxyvitamin D levels were found and ultrasound, hysteroscopic, morphological and immunohistochemical features of endometrium were determined as a result of the studies conducted in women with hyperproliferative diseases of endometrium.The method of stepwise discriminatory analysis was used to identify the 13 factors that mostly contributed to the occurrence of hyperproliferative diseases of endometrium in postmenopausal women. Based on the revealed features, the principles of integrated treatment of hyperproliferative diseases of endometrium in postmenopausal women, which helps to improve somatic health, were developed and substantiated, in particular: normalization of body weight, elimination of insulin resistance and hypothyroidism, correction of vitamin D levels, as well as the use of low-dose levonorgestrel-releasing intrauterine system (IUS), which prevents hyperproliferative diseases of endometrium and intrauterine sinechias.