Artukh S. Chronomodulated radiochemotherapy for squamous cell carcinoma of the oropharyngeal zone and larynx

The research results of 108 patients with locally advanced squamous cell carcinoma of the oropharyngeal zone and larynx who have received treatment in the SI "Grigoriev Institute of medical radiology of National academy of science of Ukraine”, are expounded on in the dissertation. At present, the standard of treatment for patients with inoperable locally advanced cancer of the oropharyngeal zone and larynx is chemoradiotherapy in the classical dose fractionation mode with chemomodification with Cisplatin. However, high toxicity and low survival rates have prompted to the search for new radiochemotherapy regimens based on the circadian rhythms of tumor and healthy cells. There is also no standardized method for monitoring the efficacy of chemoradiotherapy treatment other than computed tomography, which could serve as a factor in the continuation of treatment. Based on candidate degree’s applicant’s own clinical research, a clinically new method of chronomodulated radiochemotherapy with 5-fluorouracil in the dose hypofractionation mode for treatment of patients with locally advanced squamous cell carcinoma of the oropharyngeal zone and larynx was developed, which, in comparison with classical radiotherapy, increases the two-year survival rate of patients by 20.5 % and the incidence of positive responses for treatment by 1.4 times, while not increasing radiation toxicity. The scientific data on the incidence and nature of radiation reactions in the application of conformal radiotherapy for locally advanced squamous cell carcinoma of the oropharyngeal zone and larynx at different radiation regimens in combination with radiomodification have been supplemented. Available data on the susceptibility of the tumor-associated marker SCCA, depending on the stage of the disease, have been supplemented, and scientific data on the relationship between the dynamics of tumor-associated SCCA marker changes during radiochemotherapy and the clinical efficacy of treatment, sometimes before relapse, have been specified.