The dissertation is devoted to investigation of clinical-psychopathological and pathopsychological regularities of formation of posttraumatic stress disorder (PTSD) in military servicemen who took part in military actions, the PTSD clinical variants and types of the course in order to develop diagnostic criteria and the system of an integrated differentiated therapy. In the course of performing of the dissertation, 157 servicemen of the Armed Forces of Ukraine (AFU), who had participated in military operations in Eastern Ukraine, were examined. They had different PTSD variants (51 persons with dysphoric variant of PTSD (PTSD DV), 41 persons with anxious variant of PTSD (PTSD AV), 37 persons with asthenic variant of PTSD (PTSD AsV), and 28 persons with hypochondriac variant of PTSD (PTSD HV)). These persons constituted the main group of the investigation. As a control group of investigation, there were 117 mentally healthy servicemen of AFU, who had participated in military operations in Eastern Ukraine too. In order to meet the goal and perform the tasks of the investigation, it was used the complex of below mentioned methods: clinical-psychopathological, psychometric, psychodiagnostic, and systematic-statistical ones. It was defined, that in the PTSD genesis in servicemen, who took part in military actions, a pathogenic role belonged to the “combat stress”, which was a multicomponent influence including combat (threat of death due to shelling (81.35 %), death of fellow soldiers (41.4 %)), everyday life (insufficient sleep duration, deficiency of rest (72.6 %), a poor provision with personal protective equipment and first medical aid delivery (43.9 %)), professional (an insufficient level of specialized training in peacetime (84.7 %)), and informational (an impact of a hybrid war (55.4 %)) factors. According to the results of the investigation, PTSD clinical picture in servicemen, who had participated in military actions, was presented with PTSD DV (32.5 %), AV (26.1 %), AsV (23.6 %), and HV (17.8 %). An analysis of distribution of types of the PTSD course in servicemen with a different intensity of the combat experience demonstrated a such regularities as: in servicemen with a low intensity of the combat experience predominated stable (31.5 %) and regressive (57.4 %) types of the PTSD course; in servicemen with a high intensity of the combat experience predominated progressive (49.0 %) and stable (35.2 %) types of the PTSD course; in servicemen with a moderate intensity of the combat there were no statistically significant differences on types of the PTSD course. On the base of the integrated investigation, criteria for diagnosis of different clinical variants of combat PTSD and types of their course has been developed, as well as the program of an integrated differential therapy based on principles of timeliness, complexity, differentiation, sequencing, and continuity.