Lukianenko O. Clinical and functional features of pancreatic steatosis in children with overweight and obesity

The dissertation is devoted to the improvement of diagnostics and prediction of the risk of development of pancreatic steatosis in children with overweight / obesity on the basis of study of clinical and laboratory, structural and functional features of the course of steatosis.In the study of 117 children aged 6 to 17 years - 67 children of the main group with pancreatic steatosis and overweight / obesity, 34 overweight and obese children without pancreatic steatosis and 16 children with normal weight, we found that there are clinical features a clinical course - left hypochondrium pain in a third of patients with steatosis, as well as dyspeptic complaints such as nausea (59,7%), that was significantly more common in the main group compared with children with normal weight (p<0,05). It has been established that the level of ultrasound attenuation coefficient (UAC) exceeding 2,16 dB/cm with a sensitivity of 90% and a specificity of 65% indicates the presence of pancreatic steatosis. On the basis of logistic regression analysis, the prioritized factors associated withpancreaticsteatosis were identified – body mass index(BMI)(OR=1,32; 95% CI 1,17-1,50; p=0,0001), waist circumference (WC) (OR=1,13; 95% CI 1,08-1,18; p=0,0001), cholesterol level (OR=2,29; 95% CI 1,32-4,00; p=0,00357), low density lipoprotein cholesterol (LDL-C) (OR=3,10; 95% CI 1,55-6,23; p=0,00144), non high density lipoprotein cholesterol (nonHDL) (OR=2,92; 95% CI 1,55-5,51; p=0,00096), HOMA1-IR (OR=1,35; 95% CI 1,13-1,63; p=0,0014), controlled attenuation parameter (САР) (OR=1,03; 95% CI 1,02-1,049; p=0,0014).