Stavnichenko P. Hygienic assessment and regulation of combined fungicides based on difenoconazole and new and active ingredient cyflufenamide.

The thesis is devoted to hygienic assessment of new combined fungicides on the basis of difenoconazole and new active substance cyflufenamid and scientific substantiation of norms and regulations of safe application of formulations on their basis in agriculture. The comparative toxicological evaluation of modern fungicides Dinali, Cydeli Top, Rias, Selest Trio, Selest Top, Setar, Skor, Amistar Gold, Magnello and their active substances difenoconazole, cyflufenamide, paclobutrazole, azoxystrobin, tebuconazole, propiconazole, fludioxonil, thiamethoxam has been carried out. The acceptable daily intake of the new active substance cyflufenamide was substantiated and the degree of danger to a person was estimated. The quantitative laws of migration of cyflufenamide in environmental objects of various agroclimatic zones of Ukraine were studied. Hygienic norms in soil, atmospheric air, air of working zone were scientifically substantiated. The maximum allowable levels of cyflufenamide in crops were substantiated. Field studies on the study of working conditions have been carried out at the application of the studied fungicides on agricultural crops by various methods (ventilator, rod, pre-sowing treatment), the potential risk of their adverse effects on the organism of the workers has been assessed and the rules of their safe application in the agro-industrial complex have been scientifically substantiated. The influence of various concentrations of cyflufenamide on the organoleptic properties of water, the general sanitary regime of reservoirs and the maximum allowable concentration in water of water reservoirs has been substantiated. The analytical methods for controlling the residual quantities of cyflufenamide and difenoconazole with their co-presence in water have been developed and implemented in practice.