Andrushchak M. Clinical and pathogenetic evaluation of HIV-assotiated kidney diseases

The new solution to the important task of clinical infectology was substantiated in the dissertation; this solution is based on the results of clinical and epidemiological and laboratory examination of patients with HIV-associated kidney diseases and the task was to establish the frequency and clinical variants of kidney damage in HIV infection, in-depth study of the immune status of such patients. On the basis of a survey of 292 HIV-infected patients who were on an outpatient clinic in the Chernivtsi Regional AIDS Center, 105 (36.0%) people with markers of kidney damage – albuminuria / proteinuria found. Based on the main markers of kidney damage - persistent proteinuria and GFR less than 60 ml / min / 1.73 m2 - in 16.4% of cases, the diagnosed chronic kidney disease characterized by progressive flow and developed at any stage of HIV infection. In HIV-infected kidney damage is presented in two variants - that is, interstitial (64.6 %) and glomerular (35.4 %). It has been shown that the majority of patients with HIV infection were infected with EBV (97.9 %), CMV (94.9%), and Toxoplasma gondii (51 %), mainly in the form of a latent form. The titre of serum antibodies to these pathogens did not depend on the degree of immunosuppression in HIV-infected patients in the presence or absence of clinical manifestations.