Popruha A. Studying features of the clinical course of type 2 diabetes mellitus in comorbidity with obesity, depending on the polymorphism of the gene GPx1, taking into account gender, age, hormonal and metabolic disorders and chronic systemic low-intensity inflammation.

The study included 268 patients with type 2 DM and type 2 DM in comorbidity with obesity of both sexes (123 men and 145 women) aged 40-76 years old. All patients were divided into two main groups: I - DM type 2 without obesity - 119 people; II - DM 2 types in combination with obesity - 149 subjects. Subsequently, each of the major groups is divided into groups according to: duration of type 2 DM, age, sex, polymorphism Pro197Leu of the gene GPx1. Comparing the study data between the major groups, insufficient control of both carbohydrate and lipid metabolism was detected, but resalts in the group of obese patients showed significantly higher results. Significant increase in the content of leptin, I-HOMA, C-peptide in the group of patients with type 2 DM in combination with obesity against a group of patients with type 2 DM, indicating significant metabolic abnormalities in obesity. In the study of the effect of the polymorphism Pro197Leu gene GPx1 on the clinically-metabolic course of type 2 DM and type 2 DM in comorbidity with obesity, we found a reliable relationship between the presence of the Leu allele and the increased risk of these diseases. Instead, in these patients, the carrier allele Pro can be defined as a protective factor in preventing the development of vascular complications.