Tishchenko S. Pathogenetic features of the morpho-functional state of neurons of the arcuate nucleus of the hypothalamus in arterial hypertension of different origin

The general result of the complex research into pathogenetic peculiarities of the morpho-functional state of neurons of the hypothalamic arcuate nucleus in arterial hypertension depending on its etiology and pathogenesis development has shown that the formation of steady hypertension, regardless of the etiological factor and developmental mechanisms, leads to homotypic changes in neuropeptide content, NOS isoform mRNA expression, its isoform profile and NO terminal metabolite concentration, but reveals etiology dependant features of the morpho-densitometric parameters of neuron nuclei as well as their structural and populational relationships in the ventromedial, ventrolateral, and dorsomedial subnuclei of the hypothalamic arcuate nucleus. The work has incorporated modern pathophysiological, instrumental, molecular and genetic, immunohistochemical, biochemical, morpho-densitometric studies of hypothalamic neurons in experimental arterial hypertension. The statistical analysis of the results has been done. For the first time, the two experimental models of hypertension, which are prototypes of clinical nosological forms of hypertension, namely essential (primary) and endocrine (secondary) ones, have been used to give a complex analysis of pressor-depressor relationships and morpho-desitometric parameters of the nuclei of neurons of subnuclei (ventromedial, ventrolateral, and dorsomedial) of the hypothalamic arcuate nucleus and identify key etiopathogenetic features.