Karol I. A comparative assessment of the effectiveness of modern methods of treatments of purulent-inflammatory deseases of soft tissues using nitric oxide and application sorbent

The dissertation is devoted to the study of the peculiarities of the course of purulent-inflammatory diseases of soft tissues (PIDST) under the influence of different methods of treatment in the experiment and the clinic. In the main group of experimental animals, the application sorbent contained aerosil was used and ornidazole and seratoypeptidase was immobilized on it. In the medical organizations of the main group studies with PIDST, we used this sorbent both independently and in combination with NO-therapy, the primary suture with vacuum-aspiration and NO-therapy with post-injection abscesses and phlegmons, as well as a mixture of "7novtsef" with inflammatory infiltrates. The applied methods of treatment PIDST allowed to reduce time of purification, led to a granulation and epithelization, faster normalization of body temperature and laboratory parameters, to eliminate the pain syndrome. Both in experimental animals and in the patients, in the treatment of which the application sorbent and NO-therapy were used, we managed to achieve regenerate type of cytogram and reduction of microbial contact to the critical level in the primary urgent treatment. Morphological studies in the experiment have proved to accelerate regeneration of wounds and their healing in the application of the developed application sorbent.