Borodina O. Optimization of the prediction of the course of community-acquired uncomplicated pneumonia in children on the grounds of the determination of the cytokine profile and physical development level.

Thesis is devoted to the optimization of the prediction of the course of community-acquired uncomplicated pneumonia in children on the grounds of the determination of the cytokine profile and physical development level. It has been established that children with community-acquired uncomplicated pneumonia, have an interconnection of the duration of the disease with their physical development level: the children with overweight or weight deficiency in the acute phase of the disease have a misbalance of cytokines due to predominance of anti-inflammatory cytokines (IL-1? and TNF-?). After treatment the children with body weight deficiency the level of IL-1? does not change, which could testify about the depletion of anti-inflammatory mechanisms; the level of IL-4 of the patients with overweight stays high, meanwhile its level is probably decreasing in the patients with the average physical development level as compared with the acute phase of the disease. It has been proved that there are the gender specific features of pro- and anti-inflammatory cytokines content in children with community-acquired uncomplicated pneumonia: boys show the significant difference of the content of IL-1? before and after treatment in comparison with the girls; the girls have the higher level of IL-4 before and after treatment in comparison with the same indicators of the boys group and consequently the diminished correlation of IL-1? / IL-4, which shows the more essential engaging of IL-4 to the immune reaction in girls. The most informative clinical and immunological predictors of the duration of community-acquired uncomplicated pneumonia in children have been established and the reasonable method of prediction of the course of community-acquired pneumonia in children with different level of physical development was proposed through the use of determination of an indicator of an absolute number of the fat component.