Khomenko D. Optimization of the method of cryofixation in the surgical treatment of patients with non-inflammatory diseases of the pancreas

The dissertation presents the results of experimental and clinical research, in the course of which a number of new scientific problems were solved, which allowed to achieve the goal – to significantly improve the long-term results of surgical treatment of patients with non-inflammatory diseases of the pancreas by improving the method of cryofixation. Optimization of the method of cryofixation by developing and introducing into the clinical practice a method of cryopotentiation consisting in preliminary injection into a solid malignant resectable tumor of distilled H2O for 5 min prior to the onset of local cryoablation by a cryoapplicator device Ø 30 mm from a set of a universal cryosurgical unit "Cryo-Pulse" with a double cycle with a spontaneous thawing period after 10 minutes of each freezing period and an intraoperative control of cryofixation efficacy by thermometry at discrete depths copper-constantan thermocouples of T-type with lengths (3, 8, 13 and 18 mm), has allowed to significantly increase cumulative survival of patients with non-inflammatory diseases of the pancreas in the main group (D + C + R) with an observation period of 18 months to 74,7 %, which exceeded the corresponding indicator in the comparison group (P) by 32,5 % and 25,2 % ‒ in the comparison group (C + R) at the level of significance (χ²=7,35; p=0,025).