Sych I. Synthesis, chemical and biological properties of 5-substituted derivatives of 2-thio(amino)-1,3,4-thiadiazole

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0419U002883

Thesis Registration Form

0419U002883.pdf

Applicant for

Sych Ihor V.

Specialization

15.00.02 - Фармацевтична хімія та фармакогнозія

Date of defense

07-06-2019

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The thesis is devoted to synthesis, investigation of physicochemical and biological properties of 81 new 5-substituted derivatives of 2-thio(amino)-1,3,4-thiadiazole. We have proposed preparative methods for obtaining and synthesized the indicated compo-unds. Elemental analysis, 1H NMR spectroscopy, UV and IR spectroscopy were used to confirm their structure. Pharmacological screening of obtained compounds revealed among them substances with high diuretic, antimicrobial, antifungal and anticonvulsive activity. Suggested procedures for identification, testing of impurities and active ingredient assay in the substance N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-2-nitrobenzamide can be used in the preparation of analytical normative documentation

Thesis supervisor

Perekhoda Lina O.

Official opponents

Demchenko Anatoliy М.
Kovalenko Serhii M.

Files

autoreferat--Автореферат-Сича-І.В..pdf

Дисертація-Сича-І.В..pdf

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