Moseiko O. Structural and dynamic features of atypical clinical variants of a simple form of schizophrenia (semiotic debut variants, development vectors and differential-prognostic model)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0419U003096

Applicant for

Specialization

  • 14.01.16 - Психіатрія

05-06-2019

Specialized Academic Board

Д 64.566.01

State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine"

Essay

The study resolved an important task of clinical psychiatry – based on the analysis of the structural and dynamic features of the psychopathological symptoms of SFS, semiotic variants of its debut were established, development vectors of SFS ACV were determined and the differential prognostic model of SFS ACV nosological diagnostic has been developed, what made it possible to improve the diagnostic process and broaden the concept of SFS ACV diagnostics, allowed to clearly and define differentiated diagnostic approaches, allowed to introduce a gradation of deviant clinical characteristics of symptomes and formed the predictive component of the diagnostic process. The structural features of the semiotics of the debut of SFS ACV were established. Found 8 variants of the initial complex of symptoms, which are presented in the debut of the disease: attributive, pseudo-neurotic, pseudo-obsessional, pathoaffective, psychopathic-like, parabulic, autistic, apato-abulic. The dynamic features of the vectors of development of SFS ACV were revealed. Five vectors of syndromokinesis (SK) that coexist and develop on the background of the formation of a schizophrenic defect are described: alienative, dissocial, pseudo-neurotic, paranoial and pathoassociative. SFS ACV have been identified and systematized. Based on the comparison of the types of the initial symptomatology and the vectors of SK, stratification of the levels of clinical atypia (LCA) of a SFS was formed. 4 LCA were identified and clinico-psychopathological features of patients at each level were established. Clinical and psychopathological characteristics of patients with AСV SFS have been established. For patients with 0 LCA SFS, a constellation of negative symptoms that corresponds to the “simplex complex” was found, for patients with 1 LCA SFS, socially incongruous psychopathic forms of behavior and psychomotor agitation with a loss of critical analysis of own condition were revealed, for patients with 2 LCA SFS, hypochondriacal and obsessive symptoms with stereotypical fixation on their altered condition were found, for patients with 3 LCA SFS, paralogical thinking, high-value ideas and systematized unstable delusions with persecutory plot, which did not reach the paranoid level, were revealed. A differential-prognostic model of nosological diagnostic of SFS ACV has been developed, which is based on the principle of phase-out in reflecting the evolution of clinical manifestations in the context of the diagnostic process for different LCA of a SFS.

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