Parkinson's disease is a neurodegenerative disease, the main clinical manifestations and diagnostic criteria of which are movement disorders in the form of slowness of movements (hypokinesia), rigidity, resting tremor and imbalance.
For a clinical study in the regional center of extrapyramidal diseases, a group of patients with Parkinson’s disease is scheduled to be selected according to the clinical diagnostic criteria of the brain of the British Society of the Parkinson’s Disease Society (UK Parkinson’s Disease). Clinical neurological, neuropsychological research and determination of personality characteristics of 135 patients with Parkinson's disease. Clinical and neurological examination of patients was performed according to scoring of daily activity and motor functions in accordance with the Unified Parkinson's Disease Rating Scale (UPDRS), determination of the degree of movement disorders according to the Hoehn and Yahr scale, psycho-emotional patient states using the Beck Depression Scale (BDI), Beck's Anxiety Scale, Mini-Mental State Examination (MMSE), Montreal Cognitive Test (MoCa) cognitive status score. The personal characteristics of patients with Parkinson's disease will be investigated on a scale of Temperament and Charakter Inventory TCI - 125, Cloninger C.R, Statistical data processing using modern psychodiagnostic computer system Psychometric Expert 7 Master, statistical analysis STATISTICA 5.5 (StatSoft Inc., USA).
Used of the method of parallel groups. The main group will be divided into subgroups depending on the motor variants of the disease: Parkinson patients with akinetic-rigid, rigid-trembling and trembling forms. The control group consist of 59 people of the appropriate age category with various personal characteristics.
Criteria for exclusion of subjects: the presence of a different neurodegenerative disease, atypical and secondary parkinsonism, acute cerebral circulation, intracranial neoplasms, incl. brain and its membranes, severe liquor hypertension, mental illness with psychotic symptoms, taking neuroleptics during the study or in history, surgical interventions on the brain, taking narcotic drugs in history, uncompensated endocrinological diseases, severe metabolic disorders, refusal to sign an informed patient consent.
In the dissertation work based on the use of clinical neurological, neuropsychological methods, the clinical and pathogenetic relationship between personal characteristics and motor and non-motor manifestations, features of the course of the disease and prognostic aspect was investigated for the first time. Studied the correlation of personal characteristics with various motor variants of Parkinson's disease.
The practical significance is to optimize the diagnosis of neuropsychiatric disorders in patients with Parkinson's disease and to draw the attention of neurologists to the neuropsychological aspect of the clinical picture of the disease. Early recognition of predictors or the presence of neuropsychiatric disorders in patients with Parkinson's disease allows for a number of measures to prevent their further development and influence the effectiveness of anti-parkinsonian therapy. Despite a significant number of emotional and cognitive disorders, in Parkinson's disease, there is a need to introduce psychological screening of patients with Parkinson's disease into common clinical practice. In case of revealing above-threshold levels of emotional and cognitive impairments, adequate pharmacological and psychological correction will be recommended, which will be determined by the type of disorders.
Determining the correlation between personal characteristics and motor and non-motor manifestations of Parkinson's disease will become the basis for the formation of the prognostic aspect, based on the determination of personal characteristics, will help form risk groups for a specific course of Parkinson's motor variants.
