Martynenko Y. {([1,2,4]Triazolo[1,5-c]quinazolin-2-yl)alkyl-(alkaryl-, alkhetaryl-, aryl-)}amines and their imides: synthesis, chemical modification, physico-chemical and biological properties of the synthesized compounds

The targeted search strategy of biologically active substances was developed. It combined the approaches of preparative organic chemistry and in silico, in vitro and in vivo methodology of pharmacological studies within which a number of unknown (3H-quinazolin-4-ylidene)hydrazides of N-protected aminoacids, N-acylated {([1,2,4]triazolo[1,5-c]quinazolin-2-yl)alkyl-(alkaryl-, alkhetaryl-, aryl-)}amines and 2-[(3-aminoalkyl-, alkhetaryl-, aryl-))-1H-1,2,4-triazolo-5-уl]anilines were synthesized. The targeted search strategy of biologically active substances was developed. It combined the approaches of preparative organic chemistry and in silico, in vitro and in vivo methodology of pharmacological studies within which a number of unknown (3H-quinazolin-4-ylidene)hydrazides of N-protected aminoacids, N-acylated {([1,2,4]triazolo[1,5-c]quinazolin-2-yl)alkyl-(alkaryl-, alkhetaryl-, aryl-)}amines and 2-[(3-aminoalkyl-, alkhetaryl-, aryl-))-1H-1,2,4-triazolo-5-уl]anilines were synthesized.