In the work summarise results of the introduction of the reproductive health services for organoselecting operations in 158 women with leiomyoma of the uterus (LM), including in 79 women with its isolated form and in 79 with LM with adenomyosis (AM), and the frequency of recurrence of relapses at the onset of myomectomy in the case of standart anti-reccurences programs is also specified.
It was found that the frequency of recurrence and the early detection of combined tumors was higher (71.1%), but lower for insulated LM (43.2%), because the singular grade endometriosis accumulates on the mechanics of initiations and the risk of LM manifestation after myomectomy.
Over the years, the marker of proliferations Ki-67, LM cells in AM show 8.8 times more mitotic activity (4.6±0.12%; p<0.01), lower normal myocytes (0.52±0.02%) in combined tumors, and 2.3 times lower in isolated LM (1.2±0.07%;p<0.01) due to the increase expression in 2.7 times in combined tumors ER for H-index (160.2±6.8) then in the others myocytes (58.4±2.8; p < 0.05). This mean that the possibility of hormonal promotion of the growth of plumpness, and also their recurrence of myomectomy, with a normal level of statewide hormones in the blood of young women with LM in the hips of a higher degree of its receptivity.
Perhaps , that PGR also take part in the pathogenesis of LM, because the expression was stirred up in the cells of LM in 1.8 times (64.2±4.1). It has been concluded that the agonists of GnRG in the programs of treatment of LM are not replaced by the supremacy of ER and PGR in the citines of LM and AM, so proliferative activity of their again increases the amount of the medication and the embedded hormonal function of the cells in the menstrual cycle.
It was found out that the level of the COX-2 expression in the tissues of LM from AM (72,1±6,8%) was higher in 16,8 times in combined tumor`s then in the insulated form of LM (4,3±0,5%); p < 0,05), in which COX-2 bull is 19 times larger (15,5±0,8%), lower in analogous cells in the finely shaped insulated form of LM (0.3±0,5%), lower in analogous cells in the finely shaped form of LM (0.5±0,5%),8±0.06%), which is the result of possible participation of COX-2 in the initiation of the largest early and frequent recurrence of LM after myomectomy in this contingent of patients.
The requested algorithm of sagging therapy of prolonged duration was applied for surgeries in races with a single uterine pathology of the uterus with agonists of the GnRG, hormonal contraceptives, combinations of fibrinolytic (streptokinase) and proteolytic (streptodornase) enzymes, as well as increased antiproliferation treatment (indole-3-carbinol and enihalocatechin-3-galat). The rate of recurrence was reduced from 71.1% to 14.1%, reproductive health and motherhood was recaptured in every third woman (31%) in the breakthroughs with traditional rehabilitation visits.
